Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length400 amino acids

Chemical FormulaC2025H3183N535O561S11

DescriptionStandard

        AHQQGITVLEKELAQLRLPDITGDFRIRHVGKVHYEISRLDLRSFHLPYSRISLVPNVGLQVAISNAFADLDGNWRVKLHFIRDHGSFDLRAENIYIKINLKLGSDASGKPTVDTPDCSTRISKVQVHFSGKFGWLYNLFYSAVESRFRKSLESKVCESVARSVHSDLQPYLQTLPVTARIGSTVGIDFSLVAPPAATAQYLDVKLKGEFFSLTHRSPVPFPPLPLALPPAHDRMVYFGASSYFFNTASFAYQAAGVLVFEITDSMIPKDVEFHLNTSTFSAFIPQLEQMYPDMLMKLKLFAPSAPFMNIGPAGVSLRPVVDIQAYAILPDSRLAPLFLLSLVSNVSAVIDVKSGHIVGSLKVGRMKLSLKQSDVGTFQVRMLQSIMNILASSTLLPRLN
    

Molecular Weight44351.90 Da

Isoelectric Point (pI)9.34

Net Charge (pH 7.0)8.85

Net Charge (pH 7.4) 7.94

Charge Density (pH 7.0) 0.0221

GRAVY Index0.12

Hydrophobic Moment 0.70

Boman Index0.12

Instability Index40.29

Aliphatic Index 101.38

Aromaticity 0.0975

Extinction Coeff. Reduced 28880.00

Extinction Coeff. Oxidized 29005.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0116971 VERIFIED: NO

Provenance & Taxonomy

OrganismEurypyga helias [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria