Peptide Database

Peptide NamePlatelet-derived growth factor subunit B

Function Ontology

Immunology ▸ Immune modulation ▸ Cytokine modulation

Regulatory peptide ▸ Biological regulation

Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity

Wound healing/Regeneration ▸ Wound healing

Standard StatusStandard

Sequence Length109 amino acids

Chemical FormulaC532H892N162O153S9

DescriptionStandard

        SLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVT
    

Molecular Weight12294.35 Da

Isoelectric Point (pI)9.38

Net Charge (pH 7.0)7.49

Net Charge (pH 7.4) 7.09

Charge Density (pH 7.0) 0.0687

GRAVY Index-0.16

Hydrophobic Moment 0.74

Boman Index-0.10

Instability Index40.34

Aliphatic Index 90.28

Aromaticity 0.0367

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 6000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5118.99

LogP -53.36

H-bond Donors 186.0

H-bond Acceptors 171.0

Rotatable Bonds 409.0

Heavy Atoms 856.0

Ring Count 13.0

Amide Bonds 118.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0139164 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyPDGF/VEGF growth factor family

Tax ID9606; 0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide16-60; 49-97; 53-99

Bio-Activity Profile

Function

Cytokine Growth factor PDGF VEGF growth factor family Chemoattractant Growth factor signaling

RECORD: Rec_0250140 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Saccharomyces cerevisiae [Fungus]

FamilyGrowth factor

Tax ID9606;4932

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideDisulfide-bonded therapeutic scaffold described in source text

Other ModsPhosphorylation

Bio-Activity Profile

Function

Metabolic regulation

RECORD: Rec_0252648 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Saccharomyces cerevisiae [Fungus]

FamilyPeptide/protein therapeutic

Tax ID9606;4932

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Growth factor Wound healing

PaperPubMed-linked source references: PMID:23962308; PMID:21173589; PMID:20941855; PMID:20486728; PMID:20479444; PMID:19837327; PMID:18251718 PMID23962308;21173589;20941855;20486728;20479444;19837327;18251718 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23962308/ PatentCA1340846