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MYP_000321
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Basic Information
Brevicillin
Antimicrobial
Antimicrobial ▸ Antifungal
Antiviral
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
24 amino acids
C106H165N27O39S5
Standard
Sequence
SDSVVSDIICTTFCSVTWCQSNCC
Physicochemical Analysis
2601.93 Da
4.05
-2.59
-2.87
-0.1078
0.66
0.35
0.21
40.50
68.75
0.0833
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1071.03
-15.58
43.0
42.0
80.0
177.0
3.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0014150 VERIFIED: YES
Provenance & Taxonomy
Brevibacillus sp [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
genome mining and sequence alignment. Antimicrobial substance was extracted from cell free fermented broth using diaion HP20 resin and subsequently purified by HPLC. Sequence analysis: APD analysis reveals this sequence is most similar (41.38%) to Thuricin 4A-4 C=S: 21%; V=T: 13%. GRAVY: 0.66; M Wt: 2601.967; Mol formula: C106H167N26O39S5; molar extinction coeff: 5550. Chemical modification: not yet fully established
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Toxicity
highly hemolytic
6 μg/mL
HC50
PaperBrevicillin, a novel lanthipeptide from the genus Brevibacillus with antimicrobial, antifungal and antiviral activity.
RECORD: Rec_0049030 VERIFIED: YES
Provenance & Taxonomy
Brevibacillus sp [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
genome mining and sequence alignment. Antimicrobial substance was extracted from cell free fermented broth using diaion HP20 resin and subsequently purified by HPLC. Sequence analysis: APD analysis reveals this sequence is most similar (41.38%) to Thuricin 4A-4 C=S: 21%; V=T: 13%. GRAVY: 0.66; M Wt: 2601.967; Mol formula: C106H167N26O39S5; molar extinction coeff: 5550. Chemical modification: not yet fully established
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Candida albicans MTCC 183
30-45 μg/mL
MIC
PaperBrevicillin, a novel lanthipeptide from the genus Brevibacillus with antimicrobial, antifungal and antiviral activity.
RECORD: Rec_0057459 VERIFIED: YES
Provenance & Taxonomy
Brevibacillus sp [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
genome mining and sequence alignment. Antimicrobial substance was extracted from cell free fermented broth using diaion HP20 resin and subsequently purified by HPLC. Sequence analysis: APD analysis reveals this sequence is most similar (41.38%) to Thuricin 4A-4 C=S: 21%; V=T: 13%. GRAVY: 0.66; M Wt: 2601.967; Mol formula: C106H167N26O39S5; molar extinction coeff: 5550. Chemical modification: not yet fully established
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Toxicity
HEK 293T
25-50 μg/mL
LC50
PaperBrevicillin, a novel lanthipeptide from the genus Brevibacillus with antimicrobial, antifungal and antiviral activity.
RECORD: Rec_0057634 VERIFIED: YES
Provenance & Taxonomy
Brevibacillus sp [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
genome mining and sequence alignment. Antimicrobial substance was extracted from cell free fermented broth using diaion HP20 resin and subsequently purified by HPLC. Sequence analysis: APD analysis reveals this sequence is most similar (41.38%) to Thuricin 4A-4 C=S: 21%; V=T: 13%. GRAVY: 0.66; M Wt: 2601.967; Mol formula: C106H167N26O39S5; molar extinction coeff: 5550. Chemical modification: not yet fully established
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Escherichia coli MTCC 1610
1.2 μg/mL
MIC
PaperBrevicillin, a novel lanthipeptide from the genus Brevibacillus with antimicrobial, antifungal and antiviral activity.
RECORD: Rec_0103822 VERIFIED: YES
Provenance & Taxonomy
Brevibacillus sp [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
genome mining and sequence alignment. Antimicrobial substance was extracted from cell free fermented broth using diaion HP20 resin and subsequently purified by HPLC. Sequence analysis: APD analysis reveals this sequence is most similar (41.38%) to Thuricin 4A-4 C=S: 21%; V=T: 13%. GRAVY: 0.66; M Wt: 2601.967; Mol formula: C106H167N26O39S5; molar extinction coeff: 5550. Chemical modification: not yet fully established
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Toxicity
vero cells
25 μg/mL
LC50
PaperBrevicillin, a novel lanthipeptide from the genus Brevibacillus with antimicrobial, antifungal and antiviral activity.
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