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MYP_000310
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Basic Information
PGLa-AM1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
22 amino acids
C92H168N26O25S
Standard
Sequence
GMASKAGSVLGKVAKVALKAAL
Physicochemical Analysis
2070.54 Da
10.48
3.76
3.55
0.1707
0.83
0.59
0.27
-0.28
120.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
818.96
-8.05
29.0
30.0
73.0
144.0
0.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0209040 VERIFIED: YES
Provenance & Taxonomy
Xenopus amieti [Animal]
PGLa
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
50.0 μM
MIC
PaperJ.M. Conlon et al. / Peptides 31 (2010) 989-994. Orthologs of magainin, PGLa, procaerulein-derived, and proxenopsin-derived peptides from skin secretions of the octoploid frog Xenopus amieti (Pipidae)
RECORD: Rec_0209918 VERIFIED: YES
Provenance & Taxonomy
Xenopus amieti [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Enterococcus faecium VanB R44 [
256 μg/mL
MBC
PMID31102497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31102497/
RECORD: Rec_0212505 VERIFIED: YES
Provenance & Taxonomy
Xenopus amieti [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus DMS20231 [
64 μg/mL
MIC
PMID31102497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31102497/
RECORD: Rec_0213289 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0228394 VERIFIED: YES
Provenance & Taxonomy
Xenopus amieti [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
S. pseudintermedium E140 [
8 μg/mL
MIC
PMID31102497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31102497/
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