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MYP_000279
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Basic Information
L 5 K 5 W 6
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
11 amino acids
C71H127N17O12
Standard
Sequence
KKLLKWLKKLL
Physicochemical Analysis
1410.87 Da
10.60
4.76
4.54
0.4323
-0.13
0.82
-0.13
-10.56
177.27
0.0909
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
500.21
1.85
18.0
17.0
53.0
100.0
2.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0090100 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
50 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/19544481/ PMID19544481 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19544481/
RECORD: Rec_0123225 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae
6.3 μg/mL
MIC
PMID19544481 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19544481/
RECORD: Rec_0161406 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
12688-94). Shorter peptides are inactive, while longer peptides tend to be hemolytic. This 11mer peptide is only active after inserting an Trp, a well-known membrane anchor (see Chapter 4, Wang, G. ed. 2010 Antimicrobial peptides: discovery, design and novel therapeutic strategies, CABI). Remarkably, Shai and colleagues demonstrated (Animal model:mouse) the systemic effect of an KL-peptide, K6L9, seq LKLLKKLLKKLLKLL-NH2, consisting of a mixture of L, D-amino acids, that cures neutropenic mice infected with gentamicin-sensitive P. aeruginosa and gentamicin-resistant A. baumannii Gram-negative pathogenic bacteria when administered intravenously (Braustein A et al 2004 Antimicrob Agents Chemother 48:3127-9). 9/2010; 9/2011; 7/2018 GW
Bio-Activity Profile
Antimicrobial
(Blondelle SE & Houghten RA 1992 Biochemistry 31:12688-94). Shorter peptides are inactive, while longer peptides tend to be hemolytic. This 11mer peptide is only active after inserting an Trp, a well-known membrane anchor (see Chapter 4, Wang, G. ed. 2010 Antimicrobial peptides: discovery, design
PaperDe novo generation of antimicrobial LK peptides with a single tryptophan at the critical amphipathic interface
RECORD: Rec_0164288 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus
6.3 μg/mL
MIC
PMID19544481 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19544481/
RECORD: Rec_0175124 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 36.4%, E 0.0%, T 36.4%, C 27.3% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antibacterial Toxic Antimicrobial Hemolytic Anti-Gram-positive Anti-Gram-negative
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
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