Peptide Database

Peptide NameSLAY-screened peptide P4701

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC120H185N33O29

DescriptionStandard

        TSYILRLFRFLTVTRRYFSN
    

Molecular Weight2553.96 Da

Isoelectric Point (pI)11.55

Net Charge (pH 7.0)3.40

Net Charge (pH 7.4) 3.20

Charge Density (pH 7.0) 0.1698

GRAVY Index0.04

Hydrophobic Moment 0.69

Boman Index-0.08

Instability Index49.38

Aliphatic Index 92.50

Aromaticity 0.2500

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1048.52

LogP -7.87

H-bond Donors 41.0

H-bond Acceptors 33.0

Rotatable Bonds 81.0

Heavy Atoms 182.0

Ring Count 5.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0235072 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/