Peptide Database

Peptide NameSLAY-screened peptide P2366

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC101H152N26O29

DescriptionStandard

        RHSYGSAYSKPLVYIPPGTT
    

Molecular Weight2194.44 Da

Isoelectric Point (pI)9.53

Net Charge (pH 7.0)1.84

Net Charge (pH 7.4) 1.58

Charge Density (pH 7.0) 0.0922

GRAVY Index-0.53

Hydrophobic Moment 0.31

Boman Index0.06

Instability Index11.29

Aliphatic Index 58.50

Aromaticity 0.1500

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 868.29

LogP -8.90

H-bond Donors 31.0

H-bond Acceptors 32.0

Rotatable Bonds 62.0

Heavy Atoms 156.0

Ring Count 7.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0032485 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/