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MYP_000126
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Basic Information
Subtilomycin(Bacteriocin)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
32 amino acids
C141H234N42O45S5
Standard
Sequence
TWATIGKTIVQSVKKCRTFTCGCSLGSCSNCN
Physicochemical Analysis
3397.95 Da
9.07
3.35
3.08
0.1046
0.09
0.68
0.03
20.96
57.81
0.0625
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1432.51
-21.05
57.0
54.0
112.0
233.0
3.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000845 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-positive
PaperPubMed PMID: 23736764 PMID23736764 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23736764/
RECORD: Rec_0102688 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
T1, T4 and T8 are dehydrated into Dhb. The N-terminal Dhb was unstable and further oxidized by deamination into 2-oxo butyrate. In addition, thioether or methylthioether bonds occur between the following residue pairs: S11-C15, T17-C21, T20-C23, S24-C28, and S27-C31. Showed broad spectrum antimicrobial activity against Gram-positive and Gram-negative pathogens, as well as several pathogenic Candida species. Subtilomycin possesses several desirable industrial and pharmaceutical physicochemical properties, including activity over a wide pH range, thermal resistance and water solubility. For more info, read open Access article here
Bio-Activity Profile
Antimicrobial Antifungal
PaperSubtilomycin: A New Lantibiotic from Bacillus subtilis Strain MMA7 Isolated from the Marine Sponge Haliclona simulans
RECORD: Rec_0106713 VERIFIED: YES
Provenance & Taxonomy
Hay bacillus [Bacterium]; Bacteria [Bacterium]
2; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID23801249 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23801249/
RECORD: Rec_0112620 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
N-terminal Dhb residue is oxidated
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0145416 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-negative (broad spectrum)
PaperPubMed PMID: 23736764 PMID23736764 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23736764/
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