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MYP_000118
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Basic Information
D-LAK120-P13
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
25 amino acids
C139H250N34O26
Standard
Sequence
KKLALLALKKWLPALKKLALLALKK
Physicochemical Analysis
2813.68 Da
10.85
7.75
7.54
0.3101
0.53
0.67
0.11
12.96
176.00
0.0400
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
976.88
0.86
34.0
34.0
102.0
199.0
3.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0404316 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antiplasmodial
Plasmodium falciparum 3D7
0.88±0.08 μM
EC50
PaperConformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic alpha-helical peptides. J Biol Chem. 2012 Oct 5;287(41):34120-34133. doi: 10.1074/jbc.M112.359067. PMID: 22869378. PMID22869378 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22869378/
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