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MYP_000077
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Basic Information
Peptide 6
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HCMV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
4 amino acids
C18H34N4O5
Standard
Sequence
GVLV
Physicochemical Analysis
386.49 Da
5.53
-0.24
-0.44
-0.0600
2.95
0.07
0.93
7.50
242.50
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
150.62
-0.16
5.0
5.0
11.0
27.0
0.0
3.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0315763 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Ac
Bio-Activity Profile
Antiviral
varicella-zoster virus ATCC VR-795
20 μM
EC50
PMID34502335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34502335/
RECORD: Rec_0371686 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Methyl amidation
Acylation; Methyl amidation
Bio-Activity Profile
Antiviral Anti-HCMV Entry inhibition
cytomegalovirus (HCMV) Davis strain
20 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperPeptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. | Di Micco S, Musella S, Sala M, Scala MC, Andrei G, Snoeck R, Bifulco G, Campiglia P, Fasano A. | Int J Mol Sci. 2021 Aug 30;22(17):9427. | DOI:10.3390/ijms22179427 | PMID:34502335 PMID34502335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34502335/
RECORD: Rec_0386990 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Ac
Bio-Activity Profile
Antiviral
thymidine kinase deficient
20 μM
EC50
PMID34502335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34502335/
RECORD: Rec_0413364 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Amidation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
varicella-zoster virus (VZV) TK+ VZV Strain OKA:inhibition of virus activity in human embryonic lung (HEL) cells
20 μM
EC50
PMID34502335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34502335/
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