Peptide Database

Peptide NamePeptide 6

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HCMV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length4 amino acids

Chemical FormulaC18H34N4O5

DescriptionStandard

        GVLV
    

Molecular Weight386.49 Da

Isoelectric Point (pI)5.53

Net Charge (pH 7.0)-0.24

Net Charge (pH 7.4) -0.44

Charge Density (pH 7.0) -0.0600

GRAVY Index2.95

Hydrophobic Moment 0.07

Boman Index0.93

Instability Index7.50

Aliphatic Index 242.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 150.62

LogP -0.16

H-bond Donors 5.0

H-bond Acceptors 5.0

Rotatable Bonds 11.0

Heavy Atoms 27.0

Ring Count 0.0

Amide Bonds 3.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0164693 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcylation

C-TermAmidation

Other ModsAcylation; Methyl amidation

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

Targetcytomegalovirus (HCMV) AD-169 Strain

Activity4 μM

MethodEC50

RECORD: Rec_0165728 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcylation

C-TermMethyl amidation

Other ModsAcylation; Methyl amidation

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV-2 Entry inhibition

TargetSARS-CoV-2 UC-1074 | Vero cells

Activity20 μM

MethodEC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperPeptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. | Di Micco S, Musella S, Sala M, Scala MC, Andrei G, Snoeck R, Bifulco G, Campiglia P, Fasano A. | Int J Mol Sci. 2021 Aug 30;22(17):9427. | DOI:10.3390/ijms22179427 | PMID:34502335 PMID34502335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34502335/

RECORD: Rec_0170152 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcylation

C-TermAmidation

Other ModsAcylation; Methyl amidation

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

Targetcytomegalovirus (HCMV) Davis strain

Activity20 μM

MethodEC50

RECORD: Rec_0206098 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAc

Other ModsAcylation; Methyl amidation

Bio-Activity Profile

Function

Antiviral

Targethuman cytomegalovirus

Activity20 μM

MethodEC50

RECORD: Rec_0206502 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcylation

C-TermAmidation

Other ModsAcylation; Methyl amidation

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

Targetvaricella-zoster virus (VZV) TK-VZV Strain 07-1

Activity20 μM

MethodEC50

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