Peptide Database

Peptide NameSLAY-screened peptide P4241

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC59H85N13O13

DescriptionStandard

        PIHFLAGPGYL
    

Molecular Weight1184.39 Da

Isoelectric Point (pI)7.17

Net Charge (pH 7.0)0.04

Net Charge (pH 7.4) -0.06

Charge Density (pH 7.0) 0.0041

GRAVY Index0.75

Hydrophobic Moment 0.11

Boman Index0.58

Instability Index3.16

Aliphatic Index 115.45

Aromaticity 0.1818

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 380.45

LogP -0.24

H-bond Donors 13.0

H-bond Acceptors 14.0

Rotatable Bonds 32.0

Heavy Atoms 85.0

Ring Count 5.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0124381 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/