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MYP_000070
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Basic Information
Phospholipid scramblase 1
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HBV
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HCMV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Anti-Retrovirus ▸ Anti-HTLV cross
Antiviral ▸ Anti-Retrovirus ▸ Anti-HTLV ▸ Anti-HTLV-1 cross
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Regulatory peptide ▸ Biological modulation
Standard
318 amino acids
C1565H2383N405O461S25
Standard
Sequence
MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW
Physicochemical Analysis
35048.72 Da
4.83
-12.20
-13.00
-0.0384
-0.24
0.73
0.09
52.18
71.38
0.0943
38390.00
39515.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0043523 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
PLSCR
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation Tyr69, Tyr74, Tyr1612
Bio-Activity Profile
Antiviral Entry inhibitor Anti-HIV-1
Human immunodeficiency virus type-1(HIV-1)
PaperPhospholipid scramblase 1: a protein with multiple functions via multiple molecular interactors. PMID35650588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35650588/
RECORD: Rec_0130559 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
PLSCR
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation Tyr69, Tyr74, Tyr1612
Bio-Activity Profile
Antiviral Interferon pathway modulator Anti-VSV
Vesicular stomatitis virus (VSV)
PaperPhospholipid scramblase 1 potentiates the antiviral activity of interferon. PMID15308695 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15308695/
RECORD: Rec_0172789 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
PLSCR
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation Tyr69, Tyr74, Tyr1612
Bio-Activity Profile
Antiviral Entry inhibitor Anti-HCV
Hepatitis C virus (HCV)
PaperPhospholipid scramblase 1 mediates hepatitis C virus entry into host cells. PMID21806988 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21806988/
RECORD: Rec_0174984 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
PLSCR
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation Tyr69, Tyr74, Tyr1612
Bio-Activity Profile
Antiviral Anti-EBV
Epstein-Barr virus (EBV)
PaperPhospholipid scramblase 1: a protein with multiple functions via multiple molecular interactors. PMID35650588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35650588/
RECORD: Rec_0295092 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
PLSCR
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation Tyr69, Tyr74, Tyr1612
Bio-Activity Profile
Antiviral Protein degradation regulator Anti-HBV
Hepatitis B virus(HBV)
PaperPhospholipid scramblase 1: a protein with multiple functions via multiple molecular interactors. PMID35650588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35650588/
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