Peptide Database

Peptide NameDefensin beta 118 (Beta-defensin 118)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length123 amino acids

Chemical FormulaC588H942N164O188S9

DescriptionStandard

        MKLLLLALPMLVLLPQVIPAYSGEKKCWNRSGHCRKQCKDGEAVKDTCKNLRACCVPSNEDHRQVPTTSPTPLSDSTPGSIDDILTVRFTTDYFEVSSKKDMVEESEAGWGTQTSLPDVHHSS
    

Molecular Weight13605.34 Da

Isoelectric Point (pI)6.05

Net Charge (pH 7.0)-2.19

Net Charge (pH 7.4) -2.73

Charge Density (pH 7.0) -0.0178

GRAVY Index-0.47

Hydrophobic Moment 0.64

Boman Index-0.06

Instability Index46.33

Aliphatic Index 72.85

Aromaticity 0.0488

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5628.57

LogP -63.69

H-bond Donors 199.0

H-bond Acceptors 199.0

Rotatable Bonds 446.0

Heavy Atoms 949.0

Ring Count 21.0

Amide Bonds 129.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0038501 VERIFIED: NO

Provenance & Taxonomy

OrganismHylobates lar [Animal]

FamilyBeta-defensin; Defensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetSalmonella Typhimurium

RECORD: Rec_0114736 VERIFIED: NO

Provenance & Taxonomy

OrganismHylobates lar [Animal]

FamilyBeta-defensin; Defensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetBacillus subtilis

RECORD: Rec_0207487 VERIFIED: NO

Provenance & Taxonomy

OrganismHylobates lar [Animal]

FamilyBeta-defensin; Defensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus

RECORD: Rec_0382441 VERIFIED: NO

Provenance & Taxonomy

OrganismHylobates lar [Animal]

FamilyBeta-defensin; Defensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetEscherichia coli