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MYP_000028
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Basic Information
Maximin H5r3
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
20 amino acids
C99H181N29O23
Standard
Sequence
ILGPVLGLVSRTLRRVLGIL
Physicochemical Analysis
2145.68 Da
12.00
2.76
2.56
0.1380
1.33
0.78
0.30
82.05
199.50
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
833.59
-4.49
31.0
26.0
71.0
151.0
1.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0080076 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
ed Human Immunodeficiency Virus Type 1 HIV-1
2.2 μM
EC50
PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/
RECORD: Rec_0161043 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Maximin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells
2.2 μM
EC50
PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/
RECORD: Rec_0162921 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Multifunction
CEM-SS
2.2 μM
IC50
PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/
RECORD: Rec_0380309 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Maximin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic Anticancer
CEM-SS cells
PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/
RECORD: Rec_0385651 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Maximin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 IIIB | CEM-SS cells
2.2 μM
EC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. | Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. | DOI:10.1128/AAC.01448-09 | PMID:20086159 PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/
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