Function Ontology

Browse by biological function

Results are shown as unique peptides, so repeated assay records do not duplicate the same sequence.

root classes

124137

root peptide sum

Ontology tree

Counts are shown inline beside each class name.

Antimicrobial 106657
- Antibacterial 29877
  - Anti-Gram-negative 14062
  - Anti-Gram-positive 9577
    - Anti-Staphylococcus aureus 79
    - Anti-Listeria 32
  - Bacteriolytic activity 3428
    - Bacteriolytic enzyme 26227
  - Anti-Mycobacterium 609
- Antibiotic activity 14203
- Antifungal 12051
  - Fungicidal activity 1832
  - Anti-Candida 419
  - Anti-Aspergillus 2
  - Beauverolide 2
  - Bacillomycin 1
  - Beauvericin potentiator 1
  - Iturin biosynthesis 1
- Quorum sensing modulation 329
- Short antimicrobial peptide (group 4) family 1
- Anti-biofilm 0
  - Biofilm inhibition 341
Antiviral 6799
- Anti-HIV 1525
  - Anti-HIV-1 701
  - HIV 14
- Virucidal activity 149
- Anti-Influenza virus 64
  - Anti-Influenza 308
  - Anti-Influenza B virus 1
  - influenza viruses hemagglutinin family 1
  - Anti-Influenza A 0
    - Anti-Influenza A virus 38
    - Anti-H1N1 27
    - Anti-H5N1 2
- Anti-HPV 12
- Antiretroviral 11
- Anti-DNA-virus 1
- Anti-POXVIRUS 1
- Anti-Rotavirus 1
- Anti-cytomegalovirus 1
- Antiviral adjunct 1
- Antiviral support 1
- Autophagy-associated antiviral factor 1
- Complement-associated antiviral factor 1
- Peroxisomal antiviral signaling 1
- Retroviral restriction factor 1
- Anti-Alphavirus 0
  - Anti-Semliki Forest virus 1
- Anti-Arenavirus 0
  - Anti-Mammarenavirus 0
    - Anti-Junin virus 1
    - Anti-LCMV 1
- Anti-Coronavirus 0
  - Anti-SARS-CoV-2 109
  - Anti-SARS-CoV 69
- Anti-Filovirus 0
  - Anti-Ebola virus 14
- Anti-Flavivirus 0
  - Anti-Dengue virus 59
  - Anti-West Nile virus 39
  - Anti-Japanese encephalitis virus 28
- Anti-Hepatitis virus 0
  - Anti-HCV 400
  - Anti-HBV 15
- Anti-Herpesvirus 0
  - Anti-HSV 450
    - Anti-HSV-1 9
    - Anti-HSV-2 1
  - Anti-HCMV 16
- Anti-Paramyxovirus 0
  - Anti-HPIV 165
    - Anti-HPIV3 165
- Anti-Pneumovirus 0
  - Anti-RSV 465
- Anti-Retrovirus 0
  - Anti-HTLV 9
    - Anti-HTLV-1 4
  - Anti-Lentivirus 0
    - Anti-FIV 106
- Antiviral mechanism 0
  - Viral entry inhibition 576
    - Entry inhibitor 941
  - Viral replication inhibition 536
    - Replication inhibitor 389
  - Viral fusion inhibition 466
    - Fusion inhibitor 1082
  - Viral release inhibition 81
    - Release inhibitor 21
  - Viral budding inhibition 14
    - Budding inhibitor 1
  - Pseudovirus inhibition 7
  - Viral assembly inhibition 0
    - Assembly inhibitor 79
Anticancer 8424
- Tumor Homing Peptide 660
- Tumor T-cell antigen 508
- Anti-proliferative 299
- Antitumor 159
- Apoptosis induction 96
- tumor necrosis factor family 19
- Cancer antigenic 15
- Anti-breast cancer 9
- melanoma 9
- Prostate cancer targeting 2
- Anticancer adjunct 1
- Tumor suppressor 1
- Tumor-penetrating 1
- Anti-angiogenic activity 0
  - VEGFR targeting 0
    - Anti-VEGFR2 1
- Cytotoxic anticancer activity 0
  - Cytotoxic 0
Enzyme modulation 0
- Enzyme inhibition 3665
- Receptor tyrosine kinase inhibition 0
  - VEGFR inhibition 1
    - Anti-VEGFR2 1
Enzyme / Catalytic activity 0
- Hydrolase 21177
  - Glycosidase 16500
    - Xylanase 137
  - Nuclease 285
  - Lipase 73
  - Protease/Peptidase 20
- Oxidoreductase 257
- Protease 135
  - Thiol protease 76
  - Serine protease 15
  - Bacillus protease novo type (BPN') secretion 11
  - Metalloprotease 5
  - Antiaspartic Proteases 1
  - Cytoprotective serine protease 1
- Lyase 105
- Transferase 49
  - Kinase 109
- Ligase 4
- Isomerase 3
Immunology 0
- Chemotaxis 27
- Cytokine / receptor signaling modulation 17
  - TLR inhibition 19
  - TLR4 inhibition 17
  - TNF-alpha inhibition 3
  - IL-17A inhibition 1
- Innate immunity 17
- MHC/HLA binding 8
- Adaptive immunity 7
- Adverse immune reactivity 0
  - Allergenicity 2555
    - Allergen 107
    - Allergen-specific CD4 T-cell epitope 14
    - Allergenic activity 4
  - Histamine-release modulation 52
- Chemokine signaling 0
  - Chemokine-like peptide 64
  - Chemokine-inducing activity 58
- Epitope/vaccine antigen 0
  - T-cell epitope 508
    - Allergen-specific CD4 T-cell epitope 14
  - General epitope 0
    - Mimic putative inhibitor epitopes (mimotopes) 1
- Immune cell migration 0
  - Chemotactic peptide 176
- Immune checkpoint modulation 0
  - Immune checkpoint inhibitor 2
- Immune modulation 0
  - Immunomodulatory activity 6391
  - Cytokine modulation 538
  - Immunostimulatory activity 40
- Immunomodulation 0
  - Celiac-immunogenic 1031
  - Immunogenic 258
  - Immunoregulator 56
  - Immunosuppressive 41
  - Immunogen 24
  - Immuno-oncology 19
  - Innate immune regulator 11
  - Immunotherapy 6
  - Innate immune effector 2
  - Innate immune transcription factor 2
  - Modulate immune response 2
  - Immune evasion 1
  - Immunometabolic effector 1
  - Innate immune agonist 1
  - Innate immune sensor 1
  - Innate immune signaling adaptor 1
  - NF-kappaB-mediated immune regulator 1
- Inflammation modulation 0
  - Anti-inflammatory 4264
- Innate immune defense 0
  - Innate-defense modulating 110
  - Host defense peptide 0
    - Defense peptide 751
    - Host defense activity 393
- Innate immune modulation 0
  - Mast cell modulation 59
Toxicity / Safety 0
- Cytotoxicity 21
  - Cytotoxic 8360
- Blood cell toxicity 0
  - Hemolysis 0
    - Hemolytic 10915
- Cytolysis / cell lysis 0
  - Cytolytic activity 1862
- Negative safety assay result 0
  - Non-hemolytic 41128
Antiparasitic 0
- Antiprotozoal 255
  - Anti-Trypanosoma 76
  - Anti-Toxoplasma 5
  - Antimalarial 0
    - Anti-Plasmodium 188
- Antimalarial 239
  - Anti-plasmodium 1
- Anthelminthic 93
  - Nematicidal activity 93
- Anti-Leishmania 0
  - Antileishmanial 48
- General antiparasitic 0
  - Antiparasitic 1330
Delivery / Targeting 1
- Drug delivery vehicle 2152
  - Drug delivery 280
- Barrier transport 0
  - Blood-brain barrier shuttle 0
    - BBB shuttle 146
    - Blood-Brain Barrier 142
- Cell penetration 0
  - Cell-penetrating peptide 1389
    - Cell-penetrating 91
- Targeting ligand 0
  - Targeting 117
  - Vpr-targeting 14
  - Prostate cancer targeting 2
  - Angiogenic vessel targeting 1
  - Endothelial targeting peptide 1
  - MMP-targeting 1
- Tumor targeting 0
  - Tumor-targeting peptide 2
Cardiovascular 500
- Blood pressure regulation 0
  - Antihypertensive 3293
  - Blood pressure lowering / Hypotensive activity 1
- Vascular tone modulation 0
  - Vasoactive peptide 408
  - Vasodilatory activity 297
  - Vasoconstrictor activity 98
Metabolic 1302
- Glucose metabolism 680
  - Antidiabetic 1722
    - Hypoglycemic 14
    - Anti-diabetic 4
    - Antihypoglycemic 1
  - Diabetes-related activity 0
    - Type 1 diabetes-related 577
    - Type 2 diabetes-related 102
- Appetite and feeding regulation 0
  - Feeding regulator 287
- Lipid metabolism 0
  - Lipid-lowering activity 82
  - Cholesterol-lowering 46
  - Anti-obesity 13
- Redox / Antioxidant 0
  - Antioxidant 1
- Uric acid metabolism 0
  - Hypouricemic activity 42
Neurological / Signaling 91
- Signaling peptide 5271
- Neuromodulation 2652
- Tachykinin peptide 174
- Neuropeptide Y family 157
- Neuropeptide activity 110
- Sleep regulation 104
- Visceral muscle modulation 82
- Neuroactive peptide 43
- Analgesic/antinociceptive activity 13
- Analgesic/opioid activity 0
  - Opioid 297
  - Analgesic 288
  - Opioid receptor ligand 24
  - Opioid antagonist 15
  - Opioid agonist 6
  - opioid neuropeptide precursor family 4
  - non-opioid y-type endorphins 2
  - Anti-analgesic 1
  - Endogenous opioid found in CNS 1
  - Kappa-opioid agonist 1
- Neuromuscular and muscle activity 0
  - Myotropic activity 814
  - Myoactive peptide 82
- Pain modulation 0
  - Pronociceptive activity 114
- Receptor modulation 0
  - Agonist 696
  - Antagonist 226
Hormonal / Endocrine 78
- Hormone peptide 5807
- Hormonal activity 779
- Secretory pathway peptide 0
  - Secretory granule peptide 132
Hemostasis 11
- Antithrombotic activity 148
- Coagulation regulation 71
- Anticoagulant activity 48
- Fibrinolytic activity 27
Binding / Molecular interaction 49
- Binding activity 5389
- Protein-protein interaction 5000
- Metal binding 64
- Metal-binding peptide 59
- Receptor/ligand interaction 32
- Cell adhesion 27
- Calcium binding 26
- Surface glycoprotein binding 1
- Carbohydrate-binding peptide 0
  - Lectin 240
- Metal-binding / iron acquisition 0
  - Siderophore 68
Biomaterials / Self-assembly 0
- Interfacial properties 0
  - Surface-active peptide 57
Gastrointestinal bioactivity 167
- Gastrointestinal motility 48
Annotation / Structural annotation 56
Insecticidal/Pest control 1
- Insecticidal activity 454
Venom / Toxin 1
- Toxin 463
- Neurotoxin 290
- General toxin 0
  - Toxic 4075
  - Toxin 3711
  - Toxin-related activity 2216
  - Cytotoxin 1989
  - Toxicity 812
  - Celiac toxic 249
  - Cytotoxicity 21
  - huwentoxin-1 family 21
  - Ichthyotoxic 5
  - Antitoxin 3
  - Cytotoxic 2
  - huwentoxin-2 family 2
  - Anti-endotoxin 1
  - Microcystin analogue 1
  - Scorpion Venom Toxin 1
  - Toxin Channel Blocker 1
  - insecticidal toxin ABC family 1
  - insecticidal toxin DTX family 1
  - omega-atracotoxin type 2 family 1
  - sea anemone short toxin (type III) family 1
Annotation / Protein functional class 0
- Storage protein 241
Annotation / Sequence feature 0
- Signal peptide 466
- Nuclear export signal 292
- Peptide structural family 0
  - Cyclotide 2
- Secretory pathway 0
  - Secreted protein 98
  - Secreted peptide 47
Biotechnology / Production and expression 0
- Secretory expression optimization 466
- Secretory enzyme production 0
  - Cutinase secretion 173
  - Alkaline protease secretion 68
Developmental biology 0
- Molting regulation 90
- Development regulation 75
Host-virus interaction annotation 0
- Antiviral pathway negative regulator 2
- Pro-viral factor 1
Membrane / Ion-channel modulation 0
- Ion channel modulation 211
- Ion channel inhibition 126
- Calcium channel modulation 0
  - Calcium channel inhibitor 2124
- Chloride channel modulation 0
  - Chloride channel inhibitor 2
- Potassium channel modulation 0
  - Potassium channel inhibitor 65
- Sodium channel modulation 0
  - Sodium channel inhibitor 228
Plant bioactivity 0
- Plant defense peptide 824
Regulatory peptide 0
- Biological regulation 2953
- Biological modulation 1391
- Cell-cell communication 1015
- Stimulation activity 92
- Activation activity 48
- Cell signaling / Growth factor signaling 18
  - Growth factor activity 235
- Chemical communication 0
  - Pheromone peptide 67
- Receptor signaling modulation 0
  - Receptor inhibitor 4
Reproductive biology 0
- Reproductive modulation 369
- Male reproductive modulation 47
- Contraceptive activity 0
  - Spermicidal 44
Sensory / Food function 0
- Taste-active peptide 244
  - Bitter peptide 371
  - Umami peptide 148
  - Sweet peptide 45
Therapeutic / Biomedical activity 0
- Enzyme replacement therapy 117
- Dermatology / Cosmetic bioactivity 0
  - Skin aging modulation 0
    - Anti-aging 269
    - Collagen boosting 77
    - Anti-wrinkle 76
- Protective bioactivity 0
  - Cell protection 0
    - Cytoprotection 93
- Regenerative medicine 0
  - Tissue repair / Regeneration 19
    - Bone regeneration 10
  - Bone metabolism 0
    - Osteoanabolic activity 45
Wound healing/Regeneration 0
- Wound healing 140
- Angiogenesis modulation 28
  - Anti-angiogenic 227
  - Angiogenic 69
  - Pro-angiogenic 3
  - Angiogenesis Factor 1
  - Angiogenic vessel targeting 1
  - FGF2-axis antiangiogenic context 1
  - FGF2-binding antiangiogenic template 1
  - Therapeutic angiogenesis 1

Overview

Supplementary context for the current ontology tree.

Largest root classes

Antimicrobial 106657
Anticancer 8424
Antiviral 6799
Metabolic 1302
Cardiovascular 500
Gastrointestinal bioactivity 167
Neurological / Signaling 91
Hormonal / Endocrine 78

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