Function Ontology

Browse by biological function

Results are shown as unique peptides, so repeated assay records do not duplicate the same sequence.

root classes

296851

root peptide sum

Ontology tree

Counts are shown inline beside each class name.

Antimicrobial 107053
- Antibacterial 65347
  - Bacteriolytic activity 29300
    - Bacteriolytic enzyme 26227
  - Anti-Gram-negative 14060
  - Anti-Gram-positive 9598
    - Anti-Staphylococcus aureus 79
    - Anti-Listeria 32
  - Anti-Mycobacterium 609
- Antibiotic activity 14203
- Antifungal 12073
  - Fungicidal activity 1832
  - Anti-Candida 419
  - Anti-Aspergillus 2
- Anti-biofilm 341
  - Biofilm inhibition 341
- Quorum sensing modulation 329
- Short antimicrobial peptide (group 4) family 1
Antiviral 6791
- Antiviral mechanism 3452
  - Viral fusion inhibition 1445
    - Fusion inhibitor 1082
  - Viral entry inhibition 1369
    - Entry inhibitor 941
  - Viral replication inhibition 875
    - Replication inhibitor 389
  - Viral release inhibition 86
    - Release inhibitor 21
  - Viral assembly inhibition 79
    - Assembly inhibitor 79
  - Viral budding inhibition 15
    - Budding inhibitor 1
  - Pseudovirus inhibition 7
- Anti-HIV 2169
  - Anti-HIV-1 701
  - HIV 14
- Anti-Herpesvirus 476
  - Anti-HSV 460
    - Anti-HSV-1 9
    - Anti-HSV-2 1
  - Anti-HCMV 16
- Anti-Pneumovirus 465
  - Anti-RSV 465
- Anti-Hepatitis virus 412
  - Anti-HCV 400
  - Anti-HBV 15
- Anti-Influenza virus 404
  - Anti-Influenza 308
  - Anti-Influenza A 66
    - Anti-Influenza A virus 38
    - Anti-H1N1 27
    - Anti-H5N1 2
  - Anti-Influenza B virus 1
  - influenza viruses hemagglutinin family 1
- Anti-Paramyxovirus 165
  - Anti-HPIV 165
    - Anti-HPIV3 165
- Anti-Coronavirus 150
  - Anti-SARS-CoV-2 109
  - Anti-SARS-CoV 69
- Virucidal activity 149
- Anti-Retrovirus 115
  - Anti-Lentivirus 106
    - Anti-FIV 106
  - Anti-HTLV 9
    - Anti-HTLV-1 4
- Anti-Flavivirus 99
  - Anti-Dengue virus 59
  - Anti-West Nile virus 39
  - Anti-Japanese encephalitis virus 28
- Anti-Filovirus 14
  - Anti-Ebola virus 14
- Anti-HPV 12
- Antiretroviral 11
- Anti-Arenavirus 2
  - Anti-Mammarenavirus 2
    - Anti-Junin virus 1
    - Anti-LCMV 1
- Anti-Alphavirus 1
  - Anti-Semliki Forest virus 1
- Anti-DNA-virus 1
- Anti-POXVIRUS 1
- Anti-Rotavirus 1
- Anti-cytomegalovirus 1
- Antiviral adjunct 1
- Antiviral support 1
- Autophagy-associated antiviral factor 1
- Complement-associated antiviral factor 1
- Peroxisomal antiviral signaling 1
- Retroviral restriction factor 1
Anticancer 13621
- Cytotoxic anticancer activity 8360
  - Cytotoxic 8360
- Tumor Homing Peptide 659
- Tumor T-cell antigen 508
- Anti-proliferative 299
- Antitumor 159
- Apoptosis induction 27
- tumor necrosis factor family 19
- Anti-breast cancer 9
- Prostate cancer targeting 2
- Anti-angiogenic activity 1
  - VEGFR targeting 1
    - Anti-VEGFR2 1
- Anticancer adjunct 1
- Tumor suppressor 1
- Tumor-penetrating 1
Enzyme modulation 6498
- Enzyme inhibition 6497
  - ACE inhibition 4055
    - ACE inhibitory 4055
  - DPP-IV inhibition 706
    - DPP-IV inhibitory 706
  - Protease inhibition 533
  - Integrase inhibition 283
  - Invertebrate inhibitory neuropeptide 254
  - Amylase inhibition 146
    - Alpha-amylase inhibitory 146
  - Glycosidase inhibition 104
    - Alpha-glucosidase inhibitory 104
  - Lipase inhibition 75
  - Infection inhibition 70
  - Inhibitor 67
  - DPP-III Inhibitory 66
  - Reverse transcriptase inhibition 62
  - CaMKII Inhibitory 50
  - nNOS inhibitor 50
  - Vif multimerization inhibitor 43
  - Renin inhibition 42
    - Renin inhibitory 42
  - HMG-CoA Reductase Inhibitory 28
  - Tripeptidyl Peptidase II Inhibitory 28
  - Inhibitory neuropeptide 27
  - Maturation inhibitor 27
  - Binding inhibition 24
  - BChE Inhibitory 22
  - Biosynthesis Inhibitor 19
  - Glutamate carboxypeptidase II inhibition 18
    - Glutamate carboxypeptidase II inhibitor 18
  - Helicase inhibition 16
  - Tyrosinase inhibition 16
    - Tyrosinase inhibitory 16
  - Phosphodiesterase inhibition 14
    - CaMPDE inhibitor 14
  - Myoinhibitory peptide 12
  - Syncytium formation inhibitor 12
  - Lipoxygenase Inhibitory 11
  - Trypsin inhibitor 11
  - Xanthine oxidase inhibition 11
  - Complement inhibitor 10
  - Protein Synthesis Inhibitor 10
  - Blood coagulation cascade inhibitor 9
  - Inhibition of IL-8 production 9
  - COX-1 Inhibitory 8
  - COX-2 Inhibitory 8
  - Cell Aggregation Inhibitor 7
  - Cyclooxygenase-inhibitor 7
  - Glutamate Carboxypeptidase Inhibitor 7
  - Inhibition of ileum cells contraction 7
  - Inhibition of vas deferens cells contraction 7
  - Inhibitor Of Complement Pathway 7
  - Inhibitor Of Cytosol Alanyl Aminopeptidase 7
  - Matrix enzyme inhibition 7
    - Elastase inhibitory 7
  - XIAP inhibitory 7
  - Thrombin inhibition 6
    - Thrombin inhibitory 6
  - Tubulin-Tyrosine Ligase Inhibitor 6
  - Alanine Carboxypeptidase Inhibitor 5
  - Calpain-1 inhibitory 5
  - Growth inhibitors 5
  - Ligand Binding Inhibitor 5
  - Metalloenzyme inhibitor 5
  - Proteasome inhibitor 5
  - CPE inhibition 4
  - Cyclooxygenase-2 inhibitory 4
  - Digestion Inhibitor 4
  - Lactocepin Inhibitor 4
  - Reverse transcriptase inhibitory 4
  - Cathepsin B inhibitory 3
  - Cholesterol esterase inhibitory 3
  - Defensive-proteinase-inhibitor 3
  - HMG-CoA-reductase-inhibitor 3
  - Leucyltransferase Inhibitor 3
  - Precipitation Inhibitor 3
  - Prolyl endopeptidase inhibitory 3
  - Protein Inhibitor 3
  - Receptor inhibitory 3
  - Calpain 2 Inhibitor 2
  - Cell Growth Inhibitor 2
  - Factor XIa inhibitory 2
  - Farnesyltransferase inhibitory 2
  - Furin inhibitory 2
  - Gene expression inhibitor 2
  - IL-1beta inhibitor 2
  - Inhibition of BK-induced muscle contraction 2
  - Inhibition of TNF-alpha production 2
  - Ion Transport Inhibitor 2
  - Neprilysin Inhibitor 2
  - Peptide Inhibitor 2
  - Pheromone Inhibitor 2
  - Protein Translation Inhibitor 2
  - Protein kinase inhibitor 2
  - Protein prenyltransferase inhibitor 2
  - Protein-Binding Inhibitor 2
  - Salt Precipitation Inhibitor 2
  - Sex Pheromone Inhibitor 2
  - Xaa-Pro Inhibitor 2
  - Acylaminoacyl Peptidase Inhibitor 1
  - Alkaline Phosphatase Inhibitor 1
  - Apoptosis Inhibitor 1
  - Bile-acid-binding-inhibitor 1
  - Calcineurin inhibitor 1
  - Calpain 1 Inhibitor 1
  - Cardiac fibrosis Inhibitor 1
  - Coagulation factor VIIa peptide exosite inhibitor 1
  - Complement inhibition 1
  - Cyclophilin inhibitor 1
  - D-Ala-D-Ala Dipeptidase Inhibitor 1
  - EGFR inhibitor 1
  - Glucagon secretion inhibition 1
  - Granulopoiesis inhibition 1
  - HDAC inhibitor 1
  - Hematopoietic stem cell proliferation inhibition 1
  - Inhibition of prolyl endopeptidase 1
  - Inhibitor Of Endothelin-1 Release 1
  - Inhibitor of trypsin and chymotrypsin biosynthesis 1
  - Insulin secretion inhibition 1
  - Integrin inhibitor 1
  - Mimic putative inhibitor epitopes (mimotopes) 1
  - Mirabilis serine proteinase inhibitor family 1
  - NS5A inhibitor 1
  - Neprilysin 2 Inhibitor 1
  - Neurolysin Inhibitor 1
  - Neurotensin-inhibitor 1
  - Neutrophil Inhibitor 1
  - Pam Inhibitor 1
  - Photosynthesis Inhibitor 1
  - Post-attachment inhibitor 1
  - Prolyl oligopeptidase inhibitory 1
  - Protein Kinase C Inhibitor 1
  - Protein Prenyltransferases Inhibitor 1
  - Protein Transport Inhibitor 1
  - Protein farnesyltransferase inhibitor 1
  - Pseudolysin Inhibitor 1
  - RANKL inhibitor 1
  - Reactivation inhibitor 1
  - Thymidylate Synthase Inhibitor 1
- Receptor tyrosine kinase inhibition 1
  - VEGFR inhibition 1
    - Anti-VEGFR2 1
Enzyme / Catalytic activity 21926
- Hydrolase 21469
  - Glycosidase 16637
    - Xylanase 137
  - Nuclease 285
  - Lipase 72
  - Protease/Peptidase 20
- Oxidoreductase 257
- Transferase 138
  - Kinase 109
- Protease 124
  - Thiol protease 76
  - Serine protease 15
  - Bacillus protease novo type (BPN') secretion 11
  - Metalloprotease 5
  - Antiaspartic Proteases 1
  - Cytoprotective serine protease 1
- Lyase 105
- Ligase 4
- Isomerase 3
Immunology 11743
- Immune modulation 6892
  - Immunomodulatory activity 6329
  - Cytokine modulation 538
  - Immunostimulatory activity 40
- Inflammation modulation 4244
  - Anti-inflammatory 4244
- Adverse immune reactivity 2732
  - Allergenicity 2680
    - Allergen 107
    - Allergen-specific CD4 T-cell epitope 14
    - Allergenic activity 4
  - Histamine-release modulation 52
- Immunomodulation 1454
  - Celiac-immunogenic 1031
  - Immunogenic 258
  - Immunoregulator 56
  - Immunosuppressive 41
  - Immunogen 24
  - Immuno-oncology 19
  - Innate immune regulator 11
  - Immunotherapy 6
  - Innate immune effector 2
  - Innate immune transcription factor 2
  - Modulate immune response 2
  - Immune evasion 1
  - Immunometabolic effector 1
  - Innate immune agonist 1
  - Innate immune sensor 1
  - Innate immune signaling adaptor 1
  - NF-kappaB-mediated immune regulator 1
- Innate immune defense 1250
  - Host defense peptide 1140
    - Defense peptide 751
    - Host defense activity 393
  - Innate-defense modulating 110
- Epitope/vaccine antigen 523
  - T-cell epitope 522
    - Allergen-specific CD4 T-cell epitope 14
  - General epitope 1
    - Mimic putative inhibitor epitopes (mimotopes) 1
- Immune cell migration 176
  - Chemotactic peptide 176
- Chemokine signaling 122
  - Chemokine-like peptide 64
  - Chemokine-inducing activity 58
- Innate immune modulation 59
  - Mast cell modulation 59
- Cytokine / receptor signaling modulation 40
  - TLR inhibition 19
  - TLR4 inhibition 17
  - TNF-alpha inhibition 3
  - IL-17A inhibition 1
- MHC/HLA binding 8
- Immune checkpoint modulation 2
  - Immune checkpoint inhibitor 2
Toxicity / Safety 55674
- Negative safety assay result 41128
  - Non-hemolytic 41128
- Blood cell toxicity 10915
  - Hemolysis 10915
    - Hemolytic 10915
- Cytotoxicity 8371
  - Cytotoxic 8360
- Cytolysis / cell lysis 1862
  - Cytolytic activity 1862
Antiparasitic 1462
- General antiparasitic 1330
  - Antiparasitic 1330
- Antiprotozoal 471
  - Antimalarial 188
    - Anti-Plasmodium 188
  - Anti-Trypanosoma 76
  - Anti-Toxoplasma 5
- Antimalarial 240
  - Anti-plasmodium 1
- Anthelminthic 93
  - Nematicidal activity 93
- Anti-Leishmania 48
  - Antileishmanial 48
Delivery / Targeting 2563
- Drug delivery vehicle 2426
  - Drug delivery 280
- Cell penetration 1464
  - Cell-penetrating peptide 1464
    - Cell-penetrating 77
- Barrier transport 288
  - Blood-brain barrier shuttle 288
    - BBB shuttle 146
    - Blood-Brain Barrier 142
- Targeting ligand 136
  - Targeting 117
  - Vpr-targeting 14
  - Prostate cancer targeting 2
  - Angiogenic vessel targeting 1
  - Endothelial targeting peptide 1
  - MMP-targeting 1
- Tumor targeting 2
  - Tumor-targeting peptide 2
Cardiovascular 3997
- Blood pressure regulation 3294
  - Antihypertensive 3293
  - Blood pressure lowering / Hypotensive activity 1
- Vascular tone modulation 421
  - Vasoactive peptide 408
  - Vasodilatory activity 297
  - Vasoconstrictor activity 98
Metabolic 3266
- Glucose metabolism 1726
  - Antidiabetic 1726
    - Hypoglycemic 14
    - Anti-diabetic 4
    - Antihypoglycemic 1
  - Diabetes-related activity 679
    - Type 1 diabetes-related 577
    - Type 2 diabetes-related 102
- Appetite and feeding regulation 287
  - Feeding regulator 287
- Lipid metabolism 134
  - Lipid-lowering activity 82
  - Cholesterol-lowering 46
  - Anti-obesity 13
- Uric acid metabolism 42
  - Hypouricemic activity 42
Neurological / Signaling 16474
- Neuropeptide activity 10932
- Signaling peptide 5271
- Neuromodulation 2652
- Neuromuscular and muscle activity 815
  - Myotropic activity 814
  - Myoactive peptide 82
- Receptor modulation 696
  - Agonist 696
  - Antagonist 226
- Analgesic/opioid activity 493
  - Opioid 297
  - Analgesic 288
  - Opioid receptor ligand 24
  - Opioid antagonist 15
  - Opioid agonist 6
  - opioid neuropeptide precursor family 4
  - non-opioid y-type endorphins 2
  - Anti-analgesic 1
  - Endogenous opioid found in CNS 1
  - Kappa-opioid agonist 1
- Tachykinin peptide 174
- Neuropeptide Y family 157
- Pain modulation 114
  - Pronociceptive activity 114
- Sleep regulation 104
- Visceral muscle modulation 82
- Neuroactive peptide 43
- Analgesic/antinociceptive activity 13
Hormonal / Endocrine 6673
- Hormone peptide 5807
- Hormonal activity 779
- Secretory pathway peptide 132
  - Secretory granule peptide 132
Hemostasis 267
- Antithrombotic activity 148
- Coagulation regulation 71
- Anticoagulant activity 48
- Fibrinolytic activity 27
Binding / Molecular interaction 5729
- Binding activity 5389
- Protein-protein interaction 5000
- Carbohydrate-binding peptide 240
  - Lectin 240
- Metal-binding / iron acquisition 68
  - Siderophore 68
- Metal-binding peptide 59
- Receptor/ligand interaction 32
Biomaterials / Self-assembly 57
- Interfacial properties 57
  - Surface-active peptide 57
Other / Curated residual function label 3665
- Generic enzyme inhibition annotation 3665
Venom / Toxin 16801
- General toxin 16797
  - Cytotoxic 8360
  - Toxic 4075
  - Toxin 3640
  - Toxin-related activity 2216
  - Cytotoxin 1989
  - Toxicity 812
  - Celiac toxic 249
  - Cytotoxicity 21
  - huwentoxin-1 family 21
  - Ichthyotoxic 5
  - Antitoxin 3
  - huwentoxin-2 family 2
  - Anti-endotoxin 1
  - Scorpion Venom Toxin 1
  - Toxin Channel Blocker 1
  - insecticidal toxin ABC family 1
  - insecticidal toxin DTX family 1
  - omega-atracotoxin type 2 family 1
  - sea anemone short toxin (type III) family 1
- Toxin 463
- Neurotoxin 288
Regulatory peptide 4634
- Biological regulation 2953
- Biological modulation 1391
- Cell-cell communication 1015
- Cell signaling / Growth factor signaling 235
  - Growth factor activity 235
- Stimulation activity 92
- Chemical communication 67
  - Pheromone peptide 67
- Activation activity 48
- Receptor signaling modulation 4
  - Receptor inhibitor 4
Membrane / Ion-channel modulation 2666
- Calcium channel modulation 2124
  - Calcium channel inhibitor 2124
- Sodium channel modulation 228
  - Sodium channel inhibitor 228
- Ion channel modulation 211
- Ion channel inhibition 126
- Potassium channel modulation 65
  - Potassium channel inhibitor 65
- Chloride channel modulation 2
  - Chloride channel inhibitor 2
Annotation / Sequence feature 856
- Signal peptide 466
- Nuclear export signal 292
- Secretory pathway 98
  - Secreted protein 98
  - Secreted peptide 47
Plant bioactivity 824
- Plant defense peptide 824
Sensory / Food function 589
- Taste-active peptide 589
  - Bitter peptide 371
  - Umami peptide 148
  - Sweet peptide 45
Therapeutic / Biomedical activity 526
- Dermatology / Cosmetic bioactivity 269
  - Skin aging modulation 269
    - Anti-aging 269
    - Collagen boosting 77
    - Anti-wrinkle 76
- Enzyme replacement therapy 117
- Protective bioactivity 93
  - Cell protection 93
    - Cytoprotection 93
- Regenerative medicine 54
  - Bone metabolism 45
    - Osteoanabolic activity 45
  - Tissue repair / Regeneration 10
    - Bone regeneration 10
Biotechnology / Production and expression 466
- Secretory expression optimization 466
- Secretory enzyme production 212
  - Cutinase secretion 173
  - Alkaline protease secretion 68
Reproductive biology 460
- Reproductive modulation 369
- Male reproductive modulation 47
- Contraceptive activity 44
  - Spermicidal 44
Insecticidal/Pest control 454
- Insecticidal activity 454
Wound healing/Regeneration 438
- Angiogenesis modulation 298
  - Anti-angiogenic 226
  - Angiogenic 69
  - Pro-angiogenic 3
  - Angiogenesis Factor 1
  - Angiogenic vessel targeting 1
  - FGF2-axis antiangiogenic context 1
  - FGF2-binding antiangiogenic template 1
  - Therapeutic angiogenesis 1
- Wound healing 140
Annotation / Protein functional class 241
- Storage protein 241
Gastrointestinal bioactivity 214
- Gastrointestinal motility 48
Developmental biology 164
- Molting regulation 90
- Development regulation 75
Annotation / Structural annotation 56
Host-virus interaction annotation 3
- Antiviral pathway negative regulator 2
- Pro-viral factor 1

Overview

Supplementary context for the current ontology tree.

Largest root classes

Antimicrobial 107053
Toxicity / Safety 55674
Enzyme / Catalytic activity 21926
Venom / Toxin 16801
Neurological / Signaling 16474
Anticancer 13621
Immunology 11743
Antiviral 6791

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